Allosteric effects induced in 14-3-3 targets
Category
FP7 Project with U.S. partner
Short name and number
14_3_3 (235902)
Area
No theme specific
Description
14-3-3 proteins, found in all eukaryotic cells, are known to be important in cell-cycle regulation, apoptosis, and regulation of gene expression. They are also associated with oncogenic and neurodegenerative amyloid diseases. 14-3-3 proteins are active as homo- or heterodimers and bind more than 300 diverse target phosphoproteins, thereby forcing conformational changes or/and stabilizing active conformations in their target proteins.
Participating Countries
Czech Republic and United States.
Name of US Partner
UNIVERSITY OF PITTSBURGH
Contact
Masarykova univerzita (CZ) / SKLENAR Vladimir