Allelic Exclusion of Antibody Gene Expression
Category
FP7 Project with U.S. partner
Short name and number
Kappa Flex Mouse (235297)
Area
Health
Description
Antibody genes in B lymphocytes are assembled from multiple rearranging gene segments, enabling the immune system to protect us from a huge diversity of pathogens. Each B lymphocyte expresses only one antibody specificity on the cell surface (monospecificity), even though there is more than one allele for each antibody chain, a phenomenon termed allelic exclusion.
Participating Countries
Germany and United States.
Name of US Partner
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Contact
FRIEDRICH-ALEXANDER UNIVERSITAET ERLANGEN-NUERNBERG (DE) / WINDERL Ulrich