Thermodynamic basis of the inhibition of protein-protein interactions: design principles for the next generation of medicines
Category
FP7 Project with U.S. partner
Short name and number
PPIdesign (234796)
Area
Health
Description
Many biological processes are orchestrated by complex networks of protein-protein interactions and several diseases can be linked to deregulations of these convoluted networks. In spite of their central importance in diseases, very few existing drugs act by disrupting abnormal protein-protein interactions. The discovery of small molecule able to disrupt critical protein-protein interactions has long been considered a very difficult task.
Participating Countries
United Kingdom and United States.
Name of US Partner
Yale University
Contact
THE UNIVERSITY OF EDINBURGH (UK) / NOBLE Angela