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g- National Institutes of Health

The NIH, part of the U.S. Department of Health and Human Services, is the U.S.’s medical research agency—making important discoveries that improve health and save lives. It is the primary U.S. Federal agency for conducting and supporting medical research. The NIH mission is to seek fundamental knowledge about the nature and behaviour of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability.


NIH Exploratory/Developmental Research Grant Award (R21)

Programe Description

The R21 grant mechanism is intended to encourage exploratory/developmental research by providing support for the early and conceptual stages of project development. Its scope is: -Exploratory, novel studies that break new ground or extend previous discoveries toward new directions or applications. -High risk high reward studies that may lead to a breakthrough in a particular area, or result in novel techniques, agents, methodologies, models or applications that will impact biomedical, behavioural, or clinical research. -Projects should be distinct from those supported through the traditional R01 mechanism.

Area of Funding

Please see the funding website for the specific areas that are funded (the R21 Participating Institutes and Centres are listed at the bottom of the page): http://grants.nih.gov/grants/funding/r21.htm


National research and/or Innovation Funding Programme available to European citizens

Type of Funding

Research Grant


The overall budget amount The overall budget amount devoted to intramural and extramural R&D programs for NIH in FY 2012 is $30.107 billion16. The combined budget for direct costs for the two year project period may not exceed $275,000. No more than $200,000 may be requested in any single year. In 2011, the R21 funded 3,527 awards totaling over $714.3 million. source: AAAS R&D Budget and Policy Program: R&D in the FY 2012 Budget. http://www.aaas.org/spp/rd/fy2012/

Duration of Funding

The R03 mechanism supports a project period of up to two years. An R03 cannot be renewed.

Funding Conditions

The NIH has standardized the Exploratory/Developmental Grant (R21) application characteristics, requirements, preparation, and review procedures in order to accommodate investigator-initiated (unsolicited) grant applications.
The R21 Parent Funding Opportunity Announcement (FOA) for investigator-initiated R21 applications can be found at PA-11-261 (http://grants.nih.gov/grants/guide/pa-files/PA-11-261.html) and articulates the policies and procedures that apply to this grant mechanism.
Projects of limited cost or scope that use widely accepted approaches and methods are better suited for the R03 small grant mechanism (see R03 announcement citation:
( http://grants.nih.gov/grants/funding/r03.htm).
All investigators should consult the list of participating ICs (shown below) as well as the IC staff listed as contacts
(http://grants.nih.gov/grants/guide/contacts/parent_R21.html) to determine if an R21 application is appropriate. Investigators are strongly encouraged to consult with the appropriate NIH program administrator about their proposed research project during the concept development stage of the application.
A registration process is necessary before submission and applicants are highly encouraged to start the process at least four (4) weeks prior to the grant submission date.
Therefore, applicants should immediately check with their business official to determine whether their organization/institution is already registered in both Grants.gov and the NIH eraCommons
(http://era.nih.gov/commons/faq_commons.cfm). The NIH
will accept electronic applications only from organizations that have completed all necessary registrations.

Please read the following PDF document (extracted from printed catalogue) to obtain other useful information about DHS and eligibility language before applying:

Application Notes

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF 424 (R&R) Application Guide (http://grants.nih.gov/grants/funding/424/index.htm). Grants.gov and the NIH Guide for Grants and Contracts. Only the specific application package posted with the FOA can be used for submission.

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For general information about NIH extramural grant funding: grantsinfo@od.nih.gov Tel: +1 (301) 435-0714 http://grants.nih.gov/grants/contacts.htm

Foreign Grants Information

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BILAT-USA (Grant Agreement no: 244434) and Link2US (Grant Agreement no: 244371) Projects are co-funded by the European Union’s Capacities Programme on International Cooperation under the 7th Framework Programme for Research and Technological Cooperation.