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The NIH, part of the U.S. Department of Health and Human Services, is the U.S.’s medical research agency—making important discoveries that improve health and save lives. It is the primary U.S. Federal agency for conducting and supporting medical research. The NIH mission is to seek fundamental knowledge about the nature and behaviour of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability.


NIH Research Project Grant Program (R01)

Programe Description

The Research Project Grant (R01) is the original and historically oldest grant mechanism used by NIH. The R01 provides support for health-related research and development based on the mission of the NIH. R01s can be investigator-initiated or can be in response to a program announcement or request for application. The R01 research plan proposed by the applicant must be related to the stated program interests of one or more of the NIH Institutes and Centers based on descriptions of their programs. The Research Project (R01) grant is an award made to support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing the investigator's specific interest and competencies, based on the mission of the NIH.

Area of Funding

The NIH is comprised of Institutes and Centres that support specific areas of health-related research and almost all Institutes and Centres at the NIH fund R01 grants. Research grant applications are assigned to an Institute or Centre based on receipt and referral guidelines, and many applications are assigned to multiple Institutes and Centres as interdisciplinary and multidisciplinary research is encouraged. Each Institute and Centre maintains a website with funding opportunities and areas of interest. These should be reviewed carefully. Contact with an Institute or Centre representative may help focus the research plan based on an understanding of the mission of the Institute or Centre. Most NIH Institutes and Centres support the R01 grant mechanism. For specific information about the mission of each Institute and Centre, this link http://www.nih.gov/icd. In addition, the following NIH Offices of the Director do not accept applications, but do provide funding for investigator-initiated R01 applications: Office of Behavioural and Social Sciences Research (OBSSR) (http://obssr.od.nih.gov/index.aspx) Office of Disease Prevention (ODP) (http://odp.od.nih.gov/) Office of Rare Diseases (ORD) (http://rarediseases.info.nih.gov/) Office of Dietary Supplements (ODS) (http://dietary-supplements.info.nih.gov/) Office of Research on Women’s Health (ORWH) (http://orwh.od.nih.gov/ )


National research and/or Innovation Funding Programme available to European citizens

Type of Funding

Research Grant


The overall budget amount devoted to intramural and extramural R&D programs for the NIH for FY 2012 is $30.107 billion10. Applications for an R01 award are not limited in dollars but need to reflect the actual needs of the proposed project. Modular applications are most prevalent with modules of $25,000, up to the modular limit of $250,000. In 2011, the R01 funded 27,381 awards totaling over $10.55 billion. Source: AAAS R&D Budget and Policy Program: R&D in the FY 2012 Budget. http://www.aaas.org/spp/rd/fy2012/

Duration of Funding

Applications are generally awarded for 1 - 5 budget periods, each normally 12 months in duration. Applications can be renewed by competing for an additional project period. Supplements and amendments are allowed.

Funding Conditions

NIH still welcomes unsolicited, investigator-initiated applications. General-use “Parent Announcements”
(http://grants.nih.gov/grants/guide/parent_announcements.htm)have been created with application packages appropriate for submission of unsolicited research applications. The R01 “Parent Announcement” is PA-10-067.

R01s are most often investigator initiated in response to either the R01 Parent Announcement or a Program Announcement highlighting particular scientific areas. Requests for Applications (RFAs) may also utilize the R01 mechanism.

Grants.gov requires that all applications, including those that are investigator-initiated, be submitted in response to a specific Funding Opportunity Announcement (FOA). The FOAs are posted on Grants.gov (http://www07.grants.gov/applicants/find_grant_opportunities.jsp )and the NIH Guide for Grants and Contracts (http://grants.nih.gov/grants/guide/ ). Only the specific application package posted with the FOA can be used for submission.

Applicants may also find it helpful to seek advice from an experienced investigator and to contact the Institute or Centre most likely to fund their application – see R01 Contacts (http://grants.nih.gov/grants/guide/contacts/parent_R01.html ). NIAID provides an annotated R01 and attached summary statement on its website

A registration process is necessary before submission and applicants are highly encouraged to start the process at least four (4) weeks prior to the grant submission date. Therefore, applicants should immediately check with their business official to determine whether their organization/institution is already registered in both Grants.gov and the NIH eraCommons (http://era.nih.gov/commons/faq_commons.cfm ). The NIH will accept electronic applications only from organizations that have completed all necessary registrations.

Application Notes

Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.

For more information:

Please read the following PDF document (extracted from printed catalogue) to obtain other useful information about DHS and eligibility language before applying:

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For more information:

Foreign Grants Information

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BILAT-USA (Grant Agreement no: 244434) and Link2US (Grant Agreement no: 244371) Projects are co-funded by the European Union’s Capacities Programme on International Cooperation under the 7th Framework Programme for Research and Technological Cooperation.