CryoEm structure of gamma secretase: a key component in Alzheimer neurodegenerative disease
FP7 Project with U.S. partner
Short name and number
Alzheimer disease (AD) is characterised by the accumulation of beta amyloid peptide cut from a transmembrane precursor. A large intramembrane complex carries out the proteolysis: gamma-secretase, containing the protease presenilin and other three proteins (nicastrin, aph1, pen2). G-secretase is involved also in the proteolysis mediated signaling cascade by the transmembrane receptors Notch1 and Erb4, regulating cell growth and differentiation.
Italy and United States.
Name of US Partner
MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY CORPORATION
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA (IT) / VALLONE Beatrice